Biological Sex and the Risk of Cerebral Palsy in Victoria, Australia

Aim Males typically outnumber females in cerebral palsy (CP) cohorts. To better understand this male disadvantage' and provide insight into causal pathways to CP, this study used 1983 to 2009 Australian CP and population birth cohorts to identify associations and trends with respect to biological sex and CP.Method Within birth gestation groups, sex ratios were calculated to evaluate any male excess in the CP cohort compared with livebirths, neonatal deaths, neonatal mortality and survival rates, neonatal survivors, and CP rates in survivors. Sex- and gestation-specific trends in neonatal mortality, CP rates, and CP sex ratios were assessed by plotting their annual frequencies and fitting quadratic curves.Results Over-representation of males in preterm live births partly explained the male excess in the CP cohort after preterm birth, especially at 28 to 31weeks. Higher CP rates in male neonatal survivors also contributed to the male excess in CP, particularly at <28 and 37+weeks. Higher neonatal mortality rates in males at all gestations had little impact on the CP sex ratio. There was no clearly discernible change over time in the CP sex ratio.Interpretation Gestation-specific associations between sex and CP provide insight into causal pathways to CP and suggest sex-specific differences in response to neuroprotective strategies.