Association between allopurinol use and hip fracture in older patients.

•Oxidative stress and purinergic signalling are key mechanisms contributing to bone health and disease.•Allopurinol is a drug with powerful antioxidant effects as well as actions in purinergic signalling.•We examined the association between allopurinol use and hip fracture using routinely collected data on 17,308 older people.•Cumulative allopurinol use was not associated with a lower risk of hip fracture in this study.•This lack of effect was seen despite adjustment for multiple baseline factors including markers of physical dependency.