Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia.

Hao Huang,Xi Jiang,Jinhua Wang,Yuanyuan Li,Chun-Xiao Song,Ping Chen,Shenglai Li,Sandeep Gurbuxani,Stephen Arnovitz,Yungui Wang,Hengyou Weng,Mary Beth Neilly,Chuan He,Zejuan Li,Jianjun Chen

Cancer Letters（2016）

引用 26|浏览30

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摘要

•miR-26a is significantly down-regulated in MLL-rearranged AML.•miR-26a plays a critical anti-leukemic function both in vitro and in vivo.•TET1 is a direct target gene of miR-26a in MLL-rearranged AML.•TET1's overexpression and oncogenic role in MLL AML rely on suppression of miR-26a.•MYC mediates the transcriptional suppression of miR-26a in MLL-rearranged AML.

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关键词

MLL-rearranged leukemia,miR-26a,TET1,MYC,Post-transcription regulation

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