IMPROVEMENT OF IN VITRO STABILITY AND PHARMACOKINETICS OF hIFN-α BY FUSING THE CARBOXYL-TERMINAL PEPTIDE OF hCG β-SUBUNIT.

Natalia Ceaglio,Agustina Gugliotta,María Belén Tardivo,Dianela Cravero,Marina Etcheverrigaray,Ricardo Kratje,Marcos Oggero

Journal of Biotechnology（2016）

引用 19|浏览4

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摘要

•A strategy based on the fusion of carboxyl-terminal peptide (CTP) of hCG was applied to hIFN-α2b.•CTP remarkably improved the rhIFN-α2b stability after thermal and plasma protease treatment.•CTP fusion significantly enhanced the pharmacokinetic properties of rhIFN-α2b.•CHO-derived O-glycans of CTP resemble hCG glycans found in human normal cells.

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关键词

hIFN-α,hCG,CTP,LH,FSH,TSH,EPO,LV,LVP,Cmax,Tmax,t1/2,AUC,CLapp,2-AB

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