Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: A systematic review of the literature

•3 studies reported placental and decidual aging in pPROM and preterm birth.•Premature placental aging can be predisposing factor for adverse pregnancy outcome.•Knowledge gaps exist in our understanding of placental/membrane aging.•Lack of evidence on placental/membrane aging is due to the scarcity of studies.•Biologic and clinical markers of premature aging may predict adverse outcome.