One-pot Sonochemical Synthesis of Ferrocenyl Derivatives Via a Three-Component Reaction in Aqueous Media.

An ultrasound-assisted three-component, one-pot domino reaction with ferrocenecarboxaldehyde is herein reported. The sequence of reactions entails the allylindation and dehydrative alkylation of stabilized C-nucleophiles (e.g. electron-rich - (hetero)aromatics and stabilized enols) and N-nucleophiles (e.g. azoles). Sonochemical reactions have been performed in three different high-intensity reactors: a bath (20.3 kHz, 60W), as well as two cup horns working at 19.9 kHz (75W) and 300.5 kHz (70 W) giving a library of 18 new ferrocenyl derivatives. (C) 2015 Elsevier B.V. All rights reserved.