Asporin in compressed periodontal ligament cells inhibits bone formation
Archives of Oral Biology(2016)
摘要
•Periodontal ligament (PDL) cells and bone metabolism are greatly related.•PDL cells inhibit of bone formation by secreting anti-osteogenic factors.•PDL cells subjected to an optimal compressive force induce asporin (ASPN).•PDL cells subjected to an optimal compressive force downregulate SOST/sclerostin.•ASPN inhibits bone formation during orthodontic treatment on the compressed side.
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关键词
Periodontal ligament,Compressive force,Orthodontic tooth movement,Asporin,PLAP-1,Sclerostin
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