Asporin in compressed periodontal ligament cells inhibits bone formation

Archives of Oral Biology(2016)

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摘要
•Periodontal ligament (PDL) cells and bone metabolism are greatly related.•PDL cells inhibit of bone formation by secreting anti-osteogenic factors.•PDL cells subjected to an optimal compressive force induce asporin (ASPN).•PDL cells subjected to an optimal compressive force downregulate SOST/sclerostin.•ASPN inhibits bone formation during orthodontic treatment on the compressed side.
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关键词
Periodontal ligament,Compressive force,Orthodontic tooth movement,Asporin,PLAP-1,Sclerostin
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