Synthesis, characterization, antibacterial and antitumoral activities of mononuclear zinc complexes containing tridentate amine based ligands with N3 or N2O donor groups

Christiane Fernandes,Adolfo Horn,Olney Vieira-da-Motta,Milton M. Kanashiro,Michelle R. Rocha,Rafaela O. Moreira,Samila R. Morcelli,Bruna F. Lopes,Luciana da S. Mathias,Franz V. Borges,Layla J.H. Borges,William R. Freitas,Lorenzo C. Visentin,João C. de A. Almeida,Gerhard Schenk

Inorganica Chimica Acta（2014）

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摘要

•Structures for the complexes were determined by X-ray diffraction and NMR.•Complex (4) shows the highest cytotoxic activity promoting cell death by apoptosis.•Morphological analysis of leukemia cells by TEM confirms cell death by apoptosis.•Complex (2) reaches almost 100% of inhibition against three strains of S. aureus.•Morphological investigation by TEM suggests effect on bacteria cell division.

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关键词

Mononuclear Zn complexes,ESI(+)-MS/MS,Crystal structure,Antibacterial activity,Cytotoxic activity,Transmission electron microscopy (TEM)

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