Next-generation sequencing for genetic testing of familial colorectal cancer syndromes

Michele Simbolo,Andrea Mafficini,Marco Agostini,Corrado Pedrazzani,Chiara Bedin,Emanuele D. Urso,Donato Nitti,Giona Turri,Maria Scardoni,Matteo Fassan,Aldo Scarpa

Hereditary Cancer in Clinical Practice（2015）

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摘要

Genetic screening in families with high risk to develop colorectal cancer (CRC) prevents incurable disease and permits personalized therapeutic and follow-up strategies. The advancement of next-generation sequencing (NGS) technologies has revolutionized the throughput of DNA sequencing.

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关键词

Next generation sequencing,Colorectal adenocarcinoma,FAP,HNPCC

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