A CAUSAL DESIGN TRAJECTORY LINKS DIVERSE FORMS OF PULMONARY HYPERTENSION: EVIDENCE OF A FETAL PHENOTYPE OF ARTERIAL REMODELING UNDER THE PRINCIPLE OF MINIMUM WORK

PURPOSE: Apply an integrative interpretation of pulmonary vascular resistance (PVR) change during pulmonary hypertension progression that is theoretically independent of mechanism and timing, as translated from a simple non-equilibrium thermodynamic feedback model of adaptation.