Evaluation of red blood cell Pig-a assay and PIGRET assay in rats using chlorambucil

Mutation Research/Genetic Toxicology and Environmental Mutagenesis(2016)

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摘要
•RBC Pig-a assay and PIGRET assay detected the mutagenicity of chlorambucil.•In the RBC Pig-a assay, significant increases in MFs were observed on Day 15.•In the PIGRET assay, MFs increased significantly on Day 8.•The PIGRET assay may detect the mutagenicity earlier than the RBC Pig-a assay.
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关键词
Pig-a assay,PIGRET assay,Rat,Single dose,Chlorambucil
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