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Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation

Malathi Banda,Karen L Mckim,Lynne T Haber,Judith A Macgregor,B Bhaskar Gollapudi,Barbara L Parsons

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2015）

Cited 10|Views3
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Abstract
•Mouse lung tumors induced by vanadium pentoxide (VP) often carry Kras mutation.•ACB–PCR measured effects of inhaled aerosols of particulate VP on Kras mutation.•Accumulation of Kras mutation is not an early event in VP-induced lung carcinogenesis.
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Key words
ACB–PCR,MOA,MF,NTP,PCR,VP,WT
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