Protective Effects of Simvastatin Against Alendronate-Induced Gastric Mucosal Injury in Rats

Nathalia S. Carvalho,Mônica M. Silva,Renan O. Silva,Lucas A. D. Nicolau,Thiago S. L. Araújo,Douglas S. Costa,Nayara A. Sousa,Luan K. M. Souza,Pedro M. G. Soares,Jand Venes R. Medeiros

Digestive diseases and sciences（2015）

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摘要

It has been reported that simvastatin, a statin commonly prescribed for its anti-inflammatory and antioxidant effects, has gastroprotective effects in indomethacin and ethanol-induced gastric ulcers. However, the effects of simvastatin on alendronate-induced gastric mucosal injury remain unexplored.

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关键词

Simvastatin,Biphosphonate,Gastric damage,Antioxidant,Anti-inflammatory

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