Sirenomelia (the Mermaid Syndrome): Report of Three Cases

Sirenomelia is a rare and lethal malformation. It has been considered as an extreme form of caudal regression syndrome. This sporadic defect occurs in approximately I in 60000 newborn infants and has male predominance. Maternal diabetes mellitus is accepted to be an important predisposing factor and urogenital, gastrointestinal, cardiopulmonary and central nervous system defects are seen together with the anomaly. In this case presentation, we reported three cases of sirenomelia with multiple organ malformations. Variety of the associated anomalies and the pathological features of these rare cases may enlighten diagnosis of similar cases.