Stereoselective Total Synthesis of Iso-Cladospolide B and the 12 Membered-Macrolactone (6S,12r)-6-hydroxy-12-methyloxacyclododecane-2,5-dione
Helvetica chimica acta(2015)
Abstract
Total syntheses of iso-cladospolide B (1) and the 12-membered macrolactone (6S,12R)-6-hydroxy-12-methyloxacyclododecane-2,5-dione (2), a non-natural product, were achieved from a common intermediate starting from commercially available 1,9-nonane diol.
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Key words
Isocladospolide B,(6S,12R)-Oxacyclododecane-2,5-dione,6-hydroxy-12-methyl-,Jacobsen's hydrolytic kinetic resolution,Sharpless asymmetric dihydroxylation,Yamaguchi macrolactonization
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