Further evidence for the involvement of nitric oxide in trans-ACPD-induced suppression of AMPA responses in cultured chick Purkinje neurons

BEHAVIORAL AND BRAIN SCIENCES(1996)

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摘要
In addition to SNP and SIN-1, SNAP suppresses AMPA responses. This suppression is antagonized by carboxy-PTIO in cultured chick cerebellar Purkinje neurons. Intracellular application of cGMP shows a long-lasting suppression of AMPA responses mimicking the cerebellar LTD. These recent results demonstrate that NO can induce LTD-like suppression of AMPA responses and intracellular cGMP and cGMP-dependent protein kinase participate in this suppression.
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