Developmental changes in the expression and function of TRPC6 channels related the F-actin organization during differentiation in podocytes

•The distribution of TRPC6 channels changes with podocyte differentiation.•TRPC6 currents undergo developmental changes during podocyte differentiation.•TRPC6 inhibition leads to F-actin rearrangement only on the developmental stage.•TPRC6 is required for development of glomerulus.