Synthesis of Novel 2-Cyano-7-deaza-8-azapurine-and 2-Cyano-8-azapurine-Derived Nucleosides

Philip Wainwright,Adrian Maddaford, Michael Simms, Neil Forrest,Rebecca Glen,James Hart,Xiurong Zhang,David C. Pryde,Peter T. Stephenson,Donald S. Middleton,Thierry Guyot,Scott C. Sutton

Synlett（2011）

引用 31|浏览16

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摘要

A novel systematic approach to the synthesis of 2-cyano-7-deaza-8-azapurine derived nucleosides is described. It is shown how this chemistry was developed with the labile 2-substituted nitrile position in mind, and also how the same approach is applicable to 2-cyano-8-azapurine derived nucleosides.

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关键词

nucleosides,nitriles,protecting groups,heterocycles,glycosylation

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