Directed Functionalization of Cyano-Substituted Furans and Thiophenes with TMPMgCl·LiCl

Fernanda M Dos Santos,Joao H C Batista,Ricardo Vessecchi,Giuliano C Clososki

SYNLETT（2015）

引用 12|浏览5

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摘要

A number of novel difunctionalized furans and thiophenes has been prepared by the reaction of the cyano-substituted substrates with TMPMgClLiCl followed by the reaction with electrophiles. The crucial metalation step takes place under mild conditions allowing the isolation of desired derivatives in reasonable to good yields.

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关键词

organomagnesium reagents,ortho metalation,density functional theory,furan,thiophene,nitrile

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