Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A 3
Tetrahedron(2012)
摘要
A novel polyhydroxylated 18-membered analogue of antimycin A3 was synthesized. Our synthesis commenced with Boc-l-threonine and was achieved by way of one-pot homocoupling/ring-closing olefin metathesis reaction cascade and Sharpless asymmetric dihydroxylation. The analogue exhibited a greater anticancer activity against HeLa cells, breast MDA-MB-231 cells, and prostate PC-3 cells compared to the original antimycin A3.
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关键词
Synthesis,Anticancer,Polyhydroxylated 18-membered ring,Antimycin A3,Analogue
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