Dynamic Analysis of Irradiation of High Intensity Focused Ultrasound (HIFU) to Achieve a Living Tissue Perforation

It is well known that tissue perforation is performed by the shock waves generated by the collapse of micro bubbles due to HIFU irradiation. However, the angle-dependency between the HIFU irradiation beam and the tissue membrane has not been studied in detail so far. The objective of this study was to investigate the HIFU parameters which were the most effective in perforating the tissues with the heart beating, especially the angle dependency of the beam with the observation using high speed video camera. The result shows that the ultrasound beam should be at right angle to the membrane to perforate the tissue membrane effectively.