Comparative Proteomic Analysis of Growth Hormone Secretagogue A233 Treatment of Murine Macrophage Cells J774A.2 Indicates It Has a Role in Antiviral Innate Response.

Rebeca Martínez,Teresa Núñez de Villavicencio-Díaz,Aniel Sánchez,Yassel Ramos, Jesús Noda Ferro, Lázaro Gil González, Milagros Méndez,Elsa Rodríguez,Ernesto Marcos, Belinda Sánchez,Yordanka Masforrol,Hilda Garay,Fernando Albericio,Lisset Hermida,Luis Javier González,Eva Vonasek,Mario P Estrada,Vladimir Besada

Biochemistry and biophysics reports（2016）

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摘要

•Peptide treatment increases superoxide anion production in J774 macrophage cells.•A233 peptide treatment increases INF-γ levels in mouse splenocytes.•Mice treated with A233 significantly reduce viral load after challenge with DENV-3.•Peptide treatment may activates cytotoxic functions and exert an antiviral effect.

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关键词

DENV,GHRP-6,[d-Lys3]-GHRP-6t,GHS,IFN-γ,LPS,O2•−,RNS,ROS

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