Combination immunotherapy with oncolytic vaccinia virus and checkpoint inhibitor following local tumor irradiation

Boris Minev,Holbrook E Kohrt,Mehmet O Kilinc,Nanhai Chen,Audrey Feng, Maysam Pessian,Ulrike Geissinger,Erik Haefner,Desislava Tsoneva,Kliment Bozhilov,Idit Sagivbarfi,Xing Zhao,Narendiran Rajesekaran,Ronald Levy,Aladar A Szalay

Journal for ImmunoTherapy of Cancer（2014）

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摘要

Meeting abstracts Oncolytic virotherapy is safe and clinically active in solid tumors, however its efficacy in hematologic malignancies as well as in combination with checkpoint inhibitors and radiation is unexplored. To simulate advanced lymphoma, A20 cells were injected subcutaneously on

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关键词

Vaccinia Virus, Checkpoint Inhibitor, Oncolytic Virus, Untreated Tumor, Intratumoral Administration

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