Effect of SOCS1 overexpression on RPE cell activation by proinflammatory cytokines

Magdalena Bazewicz,Dafina Draganova,Maya Makhoul,Abdel Chtarto, Valerie Elmaleh,Liliane Tenenbaum,Laure Caspers,Catherine Bruyns,François Willermain

Neuroscience Letters（2016）

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摘要

•SOCS1 mRNA overexpression in RPE cells prevents IFNγ-induced SOCS1 mRNA increase.•SOCS1 overexpression prevents IFNγ-mediated STAT1 phosphorylation.•SOCS1 overexpression in RPE cells inhibits IFNγ-induced decrease of IL-8 secretion.•SOCS1 overexpression in RPE cells prevents IFNγ-induced MHC II and CD54 expression.•SOCS1 overexpression in RPE cells does not block TNFα- or IL-17 induced IL-8 secretion.

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关键词

RPE,SOCS1,UVEITIS,IFNγ,,IL-17,IL-8

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