structural model of the mitral valve included in a cardiovascular closed loop model. Static and dynamic validation

A minimal cardiovascular system (CVS) model including mitral valve dynamics has been previously validated in silico. It accounts for valve dynamics using a second order differential equation to simulate the physiological opening valve law. This second order equation is based on output heart signals and is very difficult to match its anatomical or physiological parameters, making this model difficult to interpret and to particularise to pathological situations.