Ethanol extract of Bojungbangam-tang (EBJT) prevents Cisplatin-induced Apoptosis in mice.

Objectives : The purpose of this study is to investigate cisplatin-induced apoptosis by ethanol extract of bojungbangam-tang (EBJT). Methods : To evaluate of anti-apoptic effects of EBJT, we examined several kinds of cell populations such as T cells, T cells and macrophages in spleen. Result : 1. EBJT inhibited cisplatin-induced cell death in spleen. 2. EBJT inhibited the death of and T cells. 3. EBJT slightly recovered the number of macrophages by cisplatin. Furthermore, cisplatin-induced upregulation of class II were inhibited by EBJT. Conclusion : EBJT prevented cisplatin-induced cell death, which could provide a clinical basic for side effects of anti-tumor therapeutics.