The Effect of Berchemia berchemiaefolia Extract in a Rat Model Acetic Acid-induced Irritable Bowel Syndrome

This study was conducted to reveal medicinal effect of Berchemia berchemiaefolia (BB) extract for induced IBS-rat model. IBS was induced by injecting acetic acid into target of Spraque-Dawley rats' colon. Control group and experimental group were categorized as follows; Group I: control group (n=5), Group II: induced IBS (n=5), Group III: induced IBS+BB LD3 extract oral administration (n=5), Group Ⅳ: induced IBS+BB LD10 extract oral administration (n=5). The measurement of AWR was performed to determine the presence of disease leading and its alleviation. Also, we analyzed hematological factors, liver functional test, inflammatory factors, stress related factors, western blot and investigated significant differences in the variables among four groups. This research result shows that feeding orally BB extract to induced IBS rat alleviates violent contraction of colon of those rats.