Genetically Modified Organisms: Concepts And Methods
GENETICALLY MODIFIED ORGANISMS AND GENETIC ENGINEERING IN RESEARCH AND THERAPY(2012)
摘要
Genetically modified organisms (GMO) raise societal, political and ethical concerns. They inspire strong resistance or, conversely, enthusiastic assent. What problems are faced in the field of genetic modification, and what scientific questions does it contribute to answer? The aim of this volume is to give an overview of genetic engineering from the technical aspects of transgenesis to their applications in research. Be it through the use of individual transfected cells or GMO, these applications cover a broad array ranging from disease-oriented research (but not only) to important perspectives for therapy. Gene therapy is fully described in full-length articles devoted to the use of this technique in cancer and in muscular disease. In this section, we shall define the following concepts: organisms, modification of germen and modification of soma, vectors and vector of expression, and transgene. We will then briefly describe the methods currently used to create GMO. A short description of the main transgenic organisms will be given in the first chapter. We do not intend to be exhaustive, but demonstrative and to give our readers objective elements for building their own opinion. Genetically modified plants are not covered in this chapter. Copyright (C) 2012 S. Karger AG, Basel
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