Predicting Error Bars For Qsar Models
COMPLIFE 2007: 3RD INTERNATIONAL SYMPOSIUM ON COMPUTATIONAL LIFE SCIENCE(2007)
摘要
Unfavorable physicochemical properties often cause drug failures. It is therefore important to take lipophilicity and water solubility into account early on in lead discovery. This study presents log D-7 models built using Gaussian Process regression, Support Vector Machines, decision trees and ridge regression algorithms based on 14556 drug discovery compounds of Bayer Schering Pharma. A blind test was conducted using 7013 new measurements from the last months. We also present independent evaluations using public data. Apart from accuracy, we discuss the quality of error bars that can be computed by Gaussian Process models, and ensemble and distance based techniques for the other modelling approaches.
更多查看译文
关键词
decision tree,prediction error,drug discovery,gaussian process regression,gaussian process,ridge regression,support vector machine,water soluble
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络