Virus-Directed Enzyme Prodrug Therapy (Vdept): A Clinical Trial Of Adenovirus-Delivered Nitroreductase (Ntr) In Combination With Cb1954 In Patients With Primary Or Secondary Liver Cancer

Daniel H Palmer,Vivien Mautner,D Hull,J Ellis,Andrew Mountain,Peter F Searle,L S Young,Winald R Gerritsen,Nicholas D James,D J Kerr

JOURNAL OF CLINICAL ONCOLOGY（2005）

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摘要

3157 Background: The bacterial enzyme nitroreductase (NTR) converts the prodrug CB1954 to a potent bifunctional alkylating agent. Since there is no human homolog of NTR, VDEPT using NTR/CB1954 is f...

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