Synthesis of ketones via organolithium addition to acid chlorides using continuous flow chemistry
RSC ADVANCES(2015)
摘要
An efficient method for the synthesis of ketones using organolithium and acid chlorides under continuous flow conditions has been developed. In contrast to standard batch chemistry, over-addition of the organolithium to the ketone for the formation of the undesired tertiary alcohol has been minimised representing a direct approach toward ketones.
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