Paraneoplastic Pemphigus Vulgaris Resulted in Takotsubo Cardiomyopathy: a Case Report

Paraneoplastic pemphigus (PNP) is an autoimmune bullous disease characterized by intractable stomatitis and is associated with different malignancies. Mortality, if associated with the disease, is usually attributed to skin lesion infection or respiratory failure. Reversible cardiomyopathy, also known as takotsubo cardiomyopathy, is a reversible left ventricular dysfunction that is always triggered by intense physical or emotional stressors. To our knowledge, this is the first case to report mortality in paraneoplastic pemphigus vulgaris from takotsubo cardiomyopathy. This case illustrates the psychosocial impact of serious skin diseases that can affect mortality even when there is a favorable prognosis.