Capture-based next-generation sequencing reveals multiple actionable mutations in cancer patients failed in traditional testing.

Jing Xie,Xiongxiong Lu,Xue Wu,Xiaoyi Lin,Chao Zhang, Xiaofang Huang,Zhili Chang,Xinjing Wang,Chenlei Wen,Xiaomei Tang,Minmin Shi,Qian Zhan,Hao Chen,Xiaxing Deng,Chenghong Peng,Hongwei Li,Yuan Fang,Yang Shao, Baiyong Shen

MOLECULAR GENETICS & GENOMIC MEDICINE（2016）

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摘要

Our study has shown that NGS-based molecular diagnosis is more sensitive and comprehensive to detect genomic alterations in cancer, and supports a direct clinical use for guiding targeted therapy.

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关键词

Next‐generation sequencing,molecular diagnosis, cancer panel,targeted therapy

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