IVF in Nonhuman Primates: Current Status and Future Directions
mag(1993)
摘要
A number of laboratories during the past two decades have contributed to the current technical status of nonhuman primate IVF. A major rationale for interest in nonhuman primate IVF was, and still is, to provide data on early development that could be directly applicable to humans. However, it is ironic that progress in production of human embryos by IVF has always been somewhat more advanced than that in nonhuman primates. Thus, although the feasibility of IVF in monkeys was demonstrated by the early 1970s, the first documented human IVF took place several years earlier (Table 2.1). In the early years of IVF research in humans and in monkeys, it was difficult to demonstrate much progress beyond fertilization itself or cleavage to 2 cells. Yet the birth of the first human IVF baby (1) preceded by several years the first demonstrations of live births in nonhuman primates derived from IVF eggs (2, 3). Nevertheless, the chronology of these events does not mean that nonhuman primate IVF cannot point the way to significant improvements in human IVF technology nor increase understanding of key areas in human reproduction. Rather, the indication is that IVF technology in nonhuman primates may be best employed to examine specific events, such as oocyte maturation, sperm capacitation, or development of new culture media, that are more difficult to study in the context of human clinical IVF.
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关键词
Rhesus Monkey,Embryo Transfer,Oocyte Maturation,Zona Pellucida,Acrosome Reaction
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