Sweet's syndrome associated with G-CSF treatment

A 66-year-old man was treated with cyclophosphamide for multiple myeloma. G-CSF (300 mu m/day for 14 days) was administered for blood stem cell collection. Twenty four hours after G-CSF was discontinued, he presented a cutaneous Sweet's syndrome, which was confirmed by histology. There were no other symptoms and neutrophil count was 6.2 x 10(9)/1. A few cases of Sweet's syndrome have been described in association with G-CSF This growth factor stimulates production of neutrophils and appears to be involved in the physiopathology of Sweet syndrome, probably in association with IL6.