[ 123 I]ICF01012 melanoma imaging and [ 131 I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models
European journal of dermatology : EJD(2015)
摘要
Background Melanin-targeting radiotracers are interesting tools for imaging and treatment of pigmented melanoma metastases. However, variation of the pigment concentration may alter the efficiency of such targeting. Objectives A clear assessment of both tumor melanin status and dosimetry are therefore prerequisites for internal radiotherapy of disseminated melanoma. Materials & Methods The melanin tracer ICF01012 was labelled with iodine-123 for melanoma imaging in pigmented murine B16F0 and human SK-Mel 3 melanomas. Results In vivo imaging showed that the uptake of [ 123 I]ICF01012 to melanomas correlated significantly with melanin content. Schedule treatment of 3 × 25 MBq [ 131 I]ICF01012 significantly reduced SK-Mel 3 tumor growth and significantly increased the median survival in treated mice. For this protocol, the calculated delivered dose was 53.2 Gy. Conclusion Radio-iodinated ICF01012 is a good candidate for both imaging and therapeutic purposes for patients with metastatic pigmented melanomas.
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关键词
dosimetry,imaging,melanin,melanoma,radiotracer,targeted radionuclide therapy
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