ChemInform Abstract: Direct Carboxylation of Thiophenes and Benzothiophenes with the Aid of EtAlCl2.

Koji Nemoto,Satoru Onozawa,Megumi Konno,Naoya Morohashi,Tetsutaro Hattori

Cheminform（2012）

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摘要

The Lewis acid mediated carboxylation of thiophenes and benzothiophenes bearing alkyl or aryl substituents at the 2- or 3-positions affords the corresponding 2- or 3-carboxylic acids in up to 90% yield.

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carboxylation

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