Chlamydia pneumoniae acute liver infection affects hepatic cholesterol and triglyceride metabolism in mice

Atherosclerosis(2015)

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摘要
•Balb/c mice were challenged with Chlamydia pneumoniae (CP) or C. trachomatis (CT).•Only CP, but not CT, was re-cultivated from the livers of inoculated mice.•Only CP infected mice showed increased cholesterol and triglycerides levels.•Hyperlipidemia was due to decreased liver cholesterol and triglycerides catabolism.•The pro-atherogenic role was species-specific for CP.
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关键词
C. pneumoniae,Cholesterol,Atherosclerosis,Cholesterol 7α-hydroxylase,Low-density lipoprotein receptor,Low-density lipoprotein receptor degrader,Carnitine palmitoyltransferase,Medium chain acyl-CoA dehydrogenase,Interleukin-1β,Inducible nitric oxide synthase
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