Pharmacodynamics Of Oral Tlr-7 Agonist Gs-9620 In Treatment-Naive Patients With Chronic Hepatitis C

E. Lawitz, D. Gruener,T. Marbury,J. Hill,L. Webster,D. Hassman,S. Pflanz, B. Massetto,M. Subramanian,J. Mchutchison,I. M. Jacobson,B. Freilich,M. Rodriguez-Torres

Journal of Hepatology（2013）

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摘要

Conclusion:Baseline PI-resistance mutations were detected at baseline in 7.8% of the patients.Their role in therapy outcome in vivo is under investigation.These results will be used for the update of the geno2pheno [HCV] tool to improve the prediction of therapy success.

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hepatitis,pharmacodynamics,treatment-naive

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