A Ph‐responsive MRI Agent That Can Be Activated Beyond the Tissue Magnetization Transfer Window
Angewandte Chemie(2015)
Abstract
A terbium-based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.
MoreTranslated text
Key words
imaging agents,lanthanides,magnetic resonance imaging,magnetization transfer,paraCEST
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined