Stereoselective Ticl4-Mediated Aldol Reactions Starting from Acylsilanes

A simple and efficient method for the preparation of beta-hydroxyacylsilanes has been developed through a TiCl4-mediated aldol reaction. A selection of Lewis acids has been assessed, and other parameters such as solvent and temperature have been optimized. These aldol reactions occur under mild conditions and furnish a selection of beta-hydroxy acylsilanes in fair-to-good yields with high syn selectivities (up to 99%).