Therapeutic effect of Chinese patent medicine “Wuhuanghu” on porcine infectious pleuropneumonia and its acute and subchronic toxicity as well as evaluation of safety pharmacology

•“Wuhuanghu” can significantly inhibit Actinobacillus pleuropneumoniae in a dose-dependent manner.•The LD50 value of “Wuhuanghu” was more than 5000mg/kg.•The target organ of “Wuhuanghu” was liver.•“Wuhuanghu” is considered as a safe veterinary medicine for oral administration.