P.1.g.052 Understanding Blood-Brain Barrier Penetration and Link to Target Engagement

V. Sinha, I. Loryan, P. De Boer, X. Langlois, C. Mackie, A. Van Peer, W. Drinkenburg, A. Vermeulen, D. Heald, M. Hammarlund-Udenaes Janssen Research and Development, Clinical Pharmacology, Beerse, Belgium Uppsala University, Translational PKPD Group Department of Pharmaceutical Biosciences, Uppsala, Sweden Janssen Research and Development, Experimental Medicine, Beerse, Belgium Janssen Research and Development, Neurosciences, Beerse, Belgium Janssen Research and Development, Pharmaceutical Development and Manufacturing Sciences, Beerse, Belgium Janssen Research and Development, Model Based Drug Development, Beerse, Belgium Janssen Research and Development, Clinical Pharmacology, Titusville, USA