Trends in the genomic epidemiology of Vibrio cholerae O1 isolated worldwide since 1961

•V. cholerae showed resistance to four drugs (erythromycin, streptomycin, trimethoprim/sulfamethoxazole and ampicillin).•Multidrug resistance among the strains arose between 1977 and 2010.•MAMA-PCR showed the dominance of ctxB classical genotype strains in the last two epochs.•A total of 65.7% strains from different geographical regions were clustered as new phage type 27.•Cluster B explains most of the hybrid toxigenic (ctxB classical/El Tor) pulsotypes.