Synthesis and evaluation of in vitro antimicrobial activity of novel 2,3-disubstituted-4-thiazolidinones from fatty acid hydrazides
Medicinal Chemistry Research(2012)
摘要
The efficient cyclocondensation reaction of fatty acid hydrazides with thioglycolic acid (TGA)/mercapto acetic acid and Thio lactic acid under anhydrous condition in the presence of catalyst anhydrous ZnCl 2 in dimethyl formamide solvent is described. The synthesis provides the product, substituted thiazolidinone, in appropriate yield. The synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, and mass spectra and these compounds were tested for in vitro antibacterial activity against the representative group of Gram-positive and Gram-negative bacteria such as Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-25922), Streptococcus pyogenes , and Klebsiella pneumonia (Clinical isolate), Methicillin resistant Staphylococcus aureus (MRSA +ve), and also tested for antifungal activity against Aspergillus fumigates, Trichophyton mentagrophytes, Penicillium marneffei, Candida albicans. Minimum inhibitory concentration, minimum bacterial concentration, and minimum fungicidal concentration were determined for the test compounds along with the reference standards used.
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关键词
Substituted thiazolidinone,Thioglycolic acid,Cyclocondensation reaction,Antimicrobial activity
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