Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway

Siyiti Amuti,Yuchun Tang, Shuang Wu,Lifen Liu,Liang Huang,Haibo Zhang,Huanhuan Li,Fen Jiang,Geying Wang,Xiaoqing Liu,Qionglan Yuan

Neurobiology of Learning and Memory（2016）

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摘要

•Neuroplastin 65 (NP65) in mice was knocked out by gene targeting.•NP65 KO mice exhibited enhanced hippocampus-dependent learning and memory.•NP65 KO mice showed anxiety-like behaviors.•NP65 deletion caused enhanced ratio of excitatory to inhibitory synapses.•NP65 deletion enhanced activation of ERK1/2 signaling.

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关键词

Neuroplastin 65,Learning and memory,Anxiety behaviors,Synaptic plasticity

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