Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

Norihiro Kato,Marie Loh,Fumihiko Takeuchi,Niek Verweij,Xu Wang,Weihua Zhang,Tanika N Kelly,Danish Saleheen,Benjamin Lehne,Irene Mateo Leach,Alexander W Drong,James Abbott,Simone Wahl,Sian-Tsung Tan,William R Scott,Gianluca Campanella,Marc Chadeau-Hyam,Uzma Afzal,Tarunveer S Ahluwalia,Marc Jan Bonder,Peng Chen,Abbas Dehghan,Todd L Edwards,Tõnu Esko,Min Jin Go,Sarah E Harris,Jaana Hartiala,Silva Kasela,Anuradhani Kasturiratne,Chiea-Chuen Khor,Marcus E Kleber,Huaixing Li,Zuan Yu Mok,Masahiro Nakatochi, Nur Sabrina Sapari,Richa Saxena,Alexandre F R Stewart,Lisette Stolk,Yasuharu Tabara,Ai Ling Teh,Ying Wu,Jer-Yuarn Wu,Yi Zhang,Imke Aits,Alexessander Da Silva Couto Alves,Shikta Das,Rajkumar Dorajoo,Jemma C Hopewell,Yun Kyoung Kim,Robert W Koivula,Jian'an Luan,Leo-Pekka Lyytikäinen,Quang N Nguyen,Mark A Pereira,Iris Postmus,Olli T Raitakari,Molly Scannell Bryan,Robert A Scott,Rossella Sorice,Vinicius Tragante,Michela Traglia,Jon White,Ken Yamamoto,Yonghong Zhang,Linda S Adair,Alauddin Ahmed,Koichi Akiyama,Rasheed Asif,Tin Aung,Inês Barroso,Andrew Bjonnes,Timothy R Braun,Hui Cai,Li-Ching Chang,Chien-Hsiun Chen,Ching-Yu Cheng,Yap-Seng Chong,Rory Collins, Regina Courtney,Gail Davies,Graciela Delgado, Loi D Do,Pieter A Doevendans,Ron T Gansevoort,Yu-Tang Gao,Tanja B Grammer,Niels Grarup,Jagvir Grewal,Dongfeng Gu,Gurpreet S Wander,Anna-Liisa Hartikainen,Stanley L Hazen,Jing He,Chew-Kiat Heng,James E Hixson,Albert Hofman,Chris Hsu,Wei Huang,Lise L N Husemoen,Joo-Yeon Hwang,Sahoko Ichihara,Michiya Igase,Masato Isono,Johanne M Justesen,Tomohiro Katsuya,Muhammad G Kibriya,Young Jin Kim,Miyako Kishimoto,Woon-Puay Koh,Katsuhiko Kohara,Meena Kumari,Kenneth Kwek,Nanette R Lee,Jeannette Lee,Jiemin Liao,Wolfgang Lieb,David C M Liewald,Tatsuaki Matsubara,Yumi Matsushita,Thomas Meitinger,Evelin Mihailov,Lili Milani,Rebecca Mills,Nina Mononen,Martina Müller-Nurasyid,Toru Nabika,Eitaro Nakashima,Hong Kiat Ng,Kjell Nikus,Teresa Nutile,Takayoshi Ohkubo,Keizo Ohnaka,Sarah Parish,Lavinia Paternoster,Hao Peng,Annette Peters, Son T Pham,Mohitha J Pinidiyapathirage,Mahfuzar Rahman,Hiromi Rakugi,Olov Rolandsson, Michelle Ann Rozario,Daniela Ruggiero,Cinzia F Sala,Ralhan Sarju,Kazuro Shimokawa,Harold Snieder,Thomas Sparsø,Wilko Spiering,John M Starr,David J Stott,Daniel O Stram,Takao Sugiyama,Silke Szymczak,W H Wilson Tang,Lin Tong,Stella Trompet, Väinö Turjanmaa,Hirotsugu Ueshima,André G Uitterlinden,Satoshi Umemura,Marja Vaarasmaki,Rob M van Dam,Wiek H van Gilst,Dirk J van Veldhuisen,Jorma S Viikari,Melanie Waldenberger,Yiqin Wang,Aili Wang,Rory Wilson,Tien-Yin Wong,Yong-Bing Xiang,Shuhei Yamaguchi,Xingwang Ye,Robin D Young,Terri L Young,Jian-Min Yuan,Xueya Zhou,Folkert W Asselbergs,Marina Ciullo,Robert Clarke,Panos Deloukas,Andre Franke,Paul W Franks,Steve Franks,Yechiel Friedlander,Myron D Gross,Zhirong Guo,Torben Hansen,Marjo-Riitta Jarvelin,Torben Jørgensen,J Wouter Jukema,Mika Kähönen,Hiroshi Kajio,Mika Kivimaki,Jong-Young Lee,Terho Lehtimäki,Allan Linneberg,Tetsuro Miki,Oluf Pedersen,Nilesh J Samani,Thorkild I A Sørensen,Ryoichi Takayanagi,Daniela Toniolo,Habibul Ahsan,Hooman Allayee,Yuan-Tsong Chen,John Danesh,Ian J Deary,Oscar H Franco,Lude Franke, Bastiaan T Heijman,Joanna D Holbrook,Aaron Isaacs,Bong-Jo Kim,Xu Lin,Jianjun Liu,Winfried März,Andres Metspalu,Karen L Mohlke,Dharambir K Sanghera,Xiao-Ou Shu,Joyce B J van Meurs,Eranga Vithana,Ananda R Wickremasinghe,Cisca Wijmenga,Bruce H W Wolffenbuttel,Mitsuhiro Yokota,Wei Zheng,Dingliang Zhu,Paolo Vineis,Soterios A Kyrtopoulos,Jos C S Kleinjans,Mark I McCarthy,Richie Soong,Christian Gieger,James Scott,Yik-Ying Teo,Jiang He,Paul Elliott,E Shyong Tai,Pim van der Harst,Jaspal S Kooner,John C Chambers

NATURE GENETICS（2015）

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摘要

John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

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epigenetics,genome wide association studies,nature,genetics

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