A Pcsk9 C-Terminal Domain Binding Fab Inhibits Pcsk9 Internalization And Restores Ldl-Uptake
Circulation(2009)
摘要
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) binds to LDL receptor (LDLR) protein, which ultimately leads to LDLR degradation and inhibition of plasma LDL cholesterol (LDL-C) clearanc...
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