Inhibition Of Type 5 Adenylyl Cyclase Rescues Cardiomyopathy Induced By Overexpressed Beta2-Adrenergic Receptors In The Heart

Lin Yan,Jean-Guillaume Dillinger,Jeffrey G. Williams,Kosaku Iwatsubo,Shumin Gao,Luke F. Fritzky,Hui Ge,Dorothy E. Vatner,Stephen F. Vatner

Circulation（2009）

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摘要

Chronic beta-adrenergic receptor (beta-AR) stimulation is deleterious and is involved in the pathogenesis of heart failure (HF). Transgenic (Tg) mice, where beta-AR signaling is chronically enhance...

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