Central glucose sensing

Since concentrations of blood glucose represent an important aspect of systemic energy homeostasis, we postulate that fluctuation of glycemia must not be only detected by pancreatic β-cells, and central neuron system (CNS) could monitor and regulate the plasma glucose levels in some stilled undefined mechanisms. In this review, we will summarize recent progress focused in the identification and characterization of actions of central glucose in the regulation of systematic energy homeostasis and glucose homeostasis, which may provide new insights into the prevention and treatment of diabetes.